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Algay, Virginie, Singh, Ishwar and Heaney, Frances (2010) Nucleoside and nucleotide analogues by catalyst free Huisgen nitrile oxide–alkyne 1,3-dipolar cycloaddition. Organic & Biomolecular Chemistry, 8. pp. 391-397. ISSN 1477-0520
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Abstract
An efficient, catalyst free, 1,3-dipolar cycloaddition strategy to conjugate nucleosides and nucleotides
with isoxazoles under atmospheric conditions and in an aqueous environment is reported. The protocol
involves chloramine-T as a practical reagent to induce in situ nitrile oxide formation and the alkyne
partner is attached to the sugar residue or the nucleobase. The reactions are regiospecific, fast and high
yielding.
| Item Type: | Article |
|---|---|
| Keywords: | Nucleoside; nucleotide analogues; catalyst free Huisgen nitrile oxide–alkyne 1,3-dipolar cycloaddition; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 4295 |
| Depositing User: | Dr. Frances Heaney |
| Date Deposited: | 09 Apr 2013 13:18 |
| Journal or Publication Title: | Organic & Biomolecular Chemistry |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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