Ringwood, John and Taussi, F. and dePaor, A.M. (2012) The effect of pulsatile blood flow on blood pressure regulatory mechanisms. Proceedings of the IEEE Conference on Control Applications (CCA), Dubrovnik.

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Abstract

This paper demonstrates that the effect of pulsatile blood flow on the baroreflex is to effectively reduce the gain of the baroreflex loop. This has important implications for both the development of integrative physiology models, which do not include pulsatile blood flow, and the use of non-pulsatile ventricular assist devices with either replace the heart or assist the heart in achieving adequate blood circulation. To elucidate the effect of the pulsatile nature of blood flow, we utilise the concept of an equivalent nonlinearity to replace the baroreflex curve, driven by a pulsatile blood flow/pressure signal, with an equivalent nonlinearity corresponding to a non-pulsatile situation. Tests are performed on a feedback model for the peripheral resistance baroreflex and conclusions made to the stability implications, using a describing function analysis.

Item Type:	Article
Keywords:	pulsatile blood flow; blood pressure; regulatory mechanisms;
Academic Unit:	Faculty of Science and Engineering > Electronic Engineering
Item ID:	6846
Depositing User:	Professor John Ringwood
Date Deposited:	19 Jan 2016 14:48
Journal or Publication Title:	Proceedings of the IEEE Conference on Control Applications (CCA), Dubrovnik
Publisher:	IEEE
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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