Ryan, Gary J. and Elmes, Robert B.P. and Quinn, Susan J. and Gunnlaugsson, Thorfinnur (2012) Synthesis and photophysical evaluations of fluorescent quaternary bipyridyl-1,8-naphthalimide conjugates as nucleic acid targeting agents. Supramolecular Chemistry, 24 (3). pp. 175-188. ISSN 1061-0278

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Abstract

A family of organic molecules containing the DNA intercalating chromophores, 4-nitro- and 4-amino 1,8-naphthalamide, conjugated to a diquat derivative by an ‘orthogonal’ phenyl spacer have been prepared, and characterized. Their binding interactions with double-stranded DNA was studied by a variety of spectroscopic techniques. These charged organic compounds are found to exhibit excellent binding affinities to DNA with binding constants comparable to those exhibited by metal complexes.

Item Type:	Article
Additional Information:	This is the preprint version of the published article, which is available at DOI: 10.1080/10610278.2011.638381
Keywords:	DNA probes; naphthalimide; fluorescence; sensors; supramolecular systems;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	6992
Identification Number:	https://doi.org/10.1080/10610278.2011.638381
Depositing User:	Robert Elmes
Date Deposited:	26 Feb 2016 16:56
Journal or Publication Title:	Supramolecular Chemistry
Publisher:	Taylor & Francis
Refereed:	Yes
Funders:	Science Foundation Ireland (SFI), Irish Research Council for Science Engineering and Technology (IRCSET)
URI:	http://www.tandfonline.com/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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