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Elmes, Robert B.P., Erby, Marialuisa, Cloonan, Suzanne M., Quinn, Susan J., Williams, D. Clive and Gunnlaugsson, Thorfinnur (2011) Quaternarized pdppz; a novel dppz derivative that causes cellular death upon light irradiation: Synthesis, DNA-binding and biological studies. Chemical Communications, 47. pp. 686-688. ISSN 1359-7345
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Abstract
The quaternarized pdppz derivative 1 was shown to bind strongly to DNA with concomitant changes in its ground and excited state photophysical properties. Furthermore, the compound also showed rapid cellular uptake, and induced apoptosis upon light irradiation in various cancer cell lines after 24 hours of incubation.
| Item Type: | Article |
|---|---|
| Keywords: | Quaternarized pdppz; novel dppz derivative; cellular death; light irradiation; Synthesis; DNA-binding; biological studies; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 6994 |
| Identification Number: | 10.1039/c0cc04303f |
| Depositing User: | Robert Elmes |
| Date Deposited: | 26 Feb 2016 16:56 |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Funders: | Science Foundation Ireland (SFI), Higher Education Authority (HEA), Irish Research Council for Science Engineering and Technology (IRCSET) |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/6994 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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