McKiernan, Margaret T. and Heaney, Frances (1996) Chemoselective formation of symmetrically linked bisisoxazole units: steps toward isoxazoline​/isoxazolidine based macrocycles. Tetrahedron Letters, 37 (26). pp. 4597-4600. ISSN 0040-4039

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Abstract

Symmetrically linked bisisoxazole derivatives can be formed from a chemselective one-pot three component reaction between oximes, dipole generating and dipole trapping components. The use of bifunctional dipole generating moieties affords bisisoxazolines (11), linked through their N-atoms. The employment of bifunctional dipolarophilic agents leads to bisisoxazolidines (3 and 4) linked via their C-5 carbon atoms.

Item Type:	Article
Keywords:	Chemoselective formation; symmetrically linked bisisoxazole units; isoxazoline​/isoxazolidine; macrocycles;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	7965
Identification Number:	https://doi.org/10.1016/0040-4039(96)00886-6
Depositing User:	Dr. Frances Heaney
Date Deposited:	24 Feb 2017 16:32
Journal or Publication Title:	Tetrahedron Letters
Publisher:	Elsevier
Refereed:	Yes
Funders:	Forbairt
URI:	http://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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