Singh, Ishwar and Zarafshani, Zoya and Lutz, Jean-François and Heaney, Frances (2009) Metal-Free “Click” Chemistry: Efficient Polymer Modification via 1,3-Dipolar Cycloaddition of Nitrile Oxides and Alkynes. Macromolecules, 42 (15). pp. 5411-5413. ISSN 0024-9297

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Abstract

Polymer chemistry, probably more than any other chemical discipline, relies on highly efficient organic reactions.1 Indeed, typical macromolecular reactions such as polymer growth (i.e., chain- or step-growth), polymer modification (i.e side-chains or chain-ends) and chain-chain coupling (i.e., block copolymer synthesis, bioconjugation) generally require high-yield and highly specific chemical reactions.2 In that context, it comes as no surprise thatmodular reactions of the “click”-type3 have recently been gaining popularity in polymer science. For instance, more than 300 articles, describing the relevance of copper-catalyzed azide/alkyne cycloadditions (CuAAC) in polymer synthesis, have been published within the last five years.4 These archetypal “click” reactions open multiple possibilities in terms of macromolecular engineering.

Item Type:	Article
Keywords:	Metal-Free; “Click” Chemistry; Polymer Modification; 1,3-Dipolar Cycloaddition; Nitrile Oxides; ;Alkynes;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	7966
Identification Number:	https://doi.org/10.1021/ma9013912
Depositing User:	Dr. Frances Heaney
Date Deposited:	24 Feb 2017 16:32
Journal or Publication Title:	Macromolecules
Publisher:	American Chemical Society
Refereed:	Yes
Funders:	German Research Foundation, Science Foundation Ireland (SFI)
URI:	http://pubs.acs.org
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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