Heaney, Frances and Bourke, Sharon (1995) The synthesis of 1,2,7,11b-Tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones. Tetrahedron Letters, 36 (41). pp. 7527-7530. ISSN 0040-4039

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Abstract

The reaction of various ethyl 3-[[2-(1-hydroxyiminoalkyl)phenyl]carbamoyl]acrylates (2) with electron deficient olefins proceeds via a sequential dipole formation, dipolar cycloaddition sequence to furnish the tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones and tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones (4) and (6). The product distribution reflects the nature of the reacting olefin and the position and extent of substitution on the acrylate moiety.

Item Type:	Article
Keywords:	synthesis; 1,2,7,11b-Tetrahydroisoxazolo[2,3-d][1,4]benzodiazepin-6(5H)-ones; 1,3,3a,9b-tetrahydroisoxazolo[4,3-c]quinolin-4(5H)-ones; ethyl 3-[[2-(1-hydroxyiminoalkyl)phenyl]carbamoyl]acrylates;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	7970
Identification Number:	https://doi.org/10.1016/0040-4039(95)01523-X
Depositing User:	Dr. Frances Heaney
Date Deposited:	24 Feb 2017 16:30
Journal or Publication Title:	Tetrahedron Letters
Publisher:	Elsevier
Refereed:	Yes
URI:	http://www.sciencedirect.com
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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