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    Deep brain stimulation may reduce tremor by preferential blockade of slower axons via antidromic activation

    García, Míriam R. and Verwoerd, Mark and Pearlmutter, Barak A. and Wellstead, Peter and Middleton, Richard H. (2011) Deep brain stimulation may reduce tremor by preferential blockade of slower axons via antidromic activation. In: 50th IEEE Conference on Decision and Control and European Control Conference (CDC-ECC), 2011. IEEE, pp. 6481-6486. ISBN 9781612848006

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    Deep brain stimulation (DBS) has been used to ameliorate essential and Parkinsonian tremor, however the detailed mechanism by which tremor reduction is achieved remains unclear. We hypothesize that DBS works by reducing time delays in the feedback paths of the motor control loops. In particular, we suggest that antidromic activation of axonal pathways induced by stimulation will preferentially block axons with longer propagation times, reducing time delays in neuronal motor circuits in a stabilising manner. We demonstrate the plausibility of this hypothesis using two simple computational models which account for a variety of experimental results, and allow us to makes a number of testable predictions.

    Item Type: Book Section
    Keywords: Satellite broadcasting; Delay; Nerve fibers; Biological system modeling; Oscillators; Joining processes; Mathematical model;
    Academic Unit: Faculty of Science and Engineering > Computer Science
    Item ID: 8117
    Identification Number:
    Depositing User: Barak Pearlmutter
    Date Deposited: 04 Apr 2017 10:15
    Publisher: IEEE
    Refereed: Yes
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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