Blumlein, Alice and Williams, Noel and McManus, Jennifer
(2017)
The mechanical properties of
individual cell spheroids.
Scientific Reports, 7 (7346).
ISSN 2045-2322
Abstract
The overall physical properties of tissues emerge in a complex manner from the properties of the
component cells and other constituent materials from which the tissue is formed, across multiple length
scales ranging from nanometres to millimetres. Recent studies have suggested that interfacial tension
between cells contributes significantly to the mechanical properties of tissues and that the overall
surface tension is determined by the ratio of adhesion tension to cortical tension. Using cavitation
rheology (CR), we have measured the interfacial properties and the elastic modulus of spheroids formed
from HEK cells. By comparing the work of bubble formation with deformation of the cell spheroid at
different length scales, we have estimated the cortical tension for HEK cells. This innovative approach
to understanding the fundamental physical properties associated with tissue mechanics may guide new
approaches for the generation of materials to replace or regenerate damaged or diseased tissues.
| Item Type: |
Article
|
| Keywords: |
mechanical properties; individual; cell spheroids; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
9242 |
| Identification Number: |
https://doi.org/10.1038/s41598-017-07813-5 |
| Depositing User: |
Jennifer McManus
|
| Date Deposited: |
12 Feb 2018 17:07 |
| Journal or Publication Title: |
Scientific Reports |
| Publisher: |
Nature Publishing Group |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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