McManus, Jennifer and Charbonneau, Patrick and Zaccarelli, Emanuela and Asherie, Neer
(2017)
The physics of protein self-assembly.
Current Opinion in Colloid and Interface Science, 22.
pp. 73-79.
ISSN 1359-0294
Abstract
Understanding protein self-assembly is important formany biological and industrial processes. Proteins can selfassemble
into crystals, filaments, gels, and other amorphous aggregates. The final forms include virus capsids and
condensed phases associated with diseases such as amyloid fibrils. Although seemingly different, these assemblies
all originate from fundamental protein interactions and are driven by similar thermodynamic and kinetic
factors. Herewe reviewrecent advances in understanding protein self-assembly through a soft condensed matter
perspective with an emphasis on three specific systems: globular proteins, viruses, and amyloid fibrils. We
conclude with a discussion of unanswered questions in the field.
| Item Type: |
Article
|
| Keywords: |
Protein;
Soft matter;
Self-assembly;
Crystallization;
Amyloids;
Virus capsids;
Patchy colloids; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
9243 |
| Identification Number: |
https://doi.org/10.1016/j.cocis.2016.02.011 |
| Depositing User: |
Jennifer McManus
|
| Date Deposited: |
12 Feb 2018 17:20 |
| Journal or Publication Title: |
Current Opinion in Colloid and Interface Science |
| Publisher: |
Elsevier |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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