Ringwood, John and Mangourova, Violeta and Guild, Sarah-Jane and Malpas, Simon (2006) A nonlinear model for vasoconstriction. In: 6th IFAC Symposium on Modelling and Control in Biomedical Systems (MCBMS06), September 2006, Reims.

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Abstract

The control of blood pressure is a complex mixture of neural, hormonal and intrinsic interactions at the level of the heart, kidney and blood vessels. While experimental approaches to understanding these interactions remain useful, it remains difficult to conduct experiments to quantify these interactions as the number of parameters increases. Thus modelling approaches can offer considerable assistance. Typical mathematical models which describe the ability of the blood vessels to change their diameter (vasoconstriction) assume linearity of operation. However, due to the interaction of multiple vasocontrictive and vasodilative effectors, there is a significant nonlinear response to the in uence of neural factors, particularly at higher levels of nerve activity (often seen in subjects with high blood pressure) which leads to low blood ow rates. This paper proposes a nonlinear mathematical model for the relationship between neural in uences (sympathetic nerve activity (SNA) and blood ow, using a feedback path to model the predominently nonlinear effect of local vasoactive modulators such as Nitric Oxide, which oppose the action of SNA. The model, the structure of which is motivated by basic physiological principles, is parameterised using a numerical optimisation method using open-loop data collected from rabbits. The model responses are shown to be in good agreement with the experimental data.

Item Type:	Conference or Workshop Item (Paper)
Keywords:	Biomedical systems; mathematical model; blood ow; nonlinear analysis; numerical optimisation;
Academic Unit:	Faculty of Science and Engineering > Electronic Engineering
Item ID:	9497
Depositing User:	Professor John Ringwood
Date Deposited:	22 May 2018 16:15
Refereed:	Yes
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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