Creaven, Bernadette S. and Devereux, Michael and Karcz, Dariusz and Kellett, Andrew and McCann, Malachy and Noble, Andy and Walsh, Maureen (2009) Copper(II) complexes of coumarin-derived Schiff bases and their anti-Candida activity. Journal of Inorganic Biochemistry, 103. pp. 1196-1203. ISSN 0162-0134

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Abstract

The condensation of 7-amino-4-methyl-coumarin (1) with a number of substituted salicylaldehydes yielded a series of Schiff bases (2a–2k) in good yields. Subsequent reaction of these ligands with copper( II) acetate yielded Cu(II) complexes (3a–3k) and some were characterised using X-ray crystallography. All of the free ligands and their metal complexes were tested for their anti-Candida activity. A number of the ligands and complexes exhibited anti-Candida activity comparable to that of the commercially available antifungal drugs, ketoconazole and Amphotericin B.

Item Type:	Article
Keywords:	Copper; Metal complexes; X-ray crystal structures; Antifungal;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	9678
Depositing User:	Dr. Malachy McCann
Date Deposited:	13 Jul 2018 12:28
Journal or Publication Title:	Journal of Inorganic Biochemistry
Publisher:	Elsevier
Refereed:	Yes
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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