Devereux, Michael and McCann, Malachy and O'Shea, Denis and O'Connor, Mark and Kiely, Eileen and McKee, Vickie and Naughton, Declan and Fisher, Anna and Kellett, Andrew and Walsh, Maureen and Egan, Denise and Deegan, Carol
(2006)
Synthesis, Superoxide DismutaseMimetic and
Anticancer Activities of Metal Complexes of
2,2-Dimethylpentanedioic Acid(2dmepdaH2) and
3,3-Dimethylpentanedioic acid(3dmepdaH2): X-Ray Crystal
Structures of [Cu(3dmepda)(bipy)]2 · 6H2Oand
[Cu(2dmepda)(bipy)(EtOH)]2 · 4EtOH (bipy = 2,2'Bipyridine).
Bioinorganic Chemistry and Applications.
pp. 1-11.
Abstract
A range of monocarboxylic acids are known to have a variety
of pharmacological effects. Salicylic acid and its derivatives,
for example, have been shown to possess anti-inflammatory
and antitumour activity [1]. Upon coordination to a suitable
metal centre, the biologically active carboxylic acids often
become more effective and desirable drugs [2]. The carboxylate
group is an important class of ligand in inorganic and
bioinorganic chemistry, metal complexes containing monocarboxylic
acids are well known, and the publication ofmany
structurally characterised examples of this class of compound
has demonstrated its versatility as an inner-sphere
ligand [3]. The coordination chemistry of dicarboxylic acids
is far less developed as polymeric products are usually obtained,
and indeed structural information for this class of
complex is relatively scarce. Recently, we have shown that the
reaction of polymeric dicarboxylate complexes of copper(II),
manganese(II), and cobalt(II) with the N,N-donor ligands
1,10-phenanthroline and 2,2�-bipyridine can lead to the
synthesis of crystalline compounds which are easily structurally
characterised by X-ray methods [4–9]. A number
of the manganese complexes have been found to exhibit
excellent catalase-mimetic activity [5, 8] and it has also been
demonstrated that N-donor derivatives of the dicarboxylate
complexes of a range of metals are very effective antifungal
agents possessing significantly different modes of action to
the state-of-the-art prescription drugs [10–12].
| Item Type: |
Article
|
| Keywords: |
Synthesis; Superoxide DismutaseMimetic; Anticancer Activities; Metal Complexes; 2,2-Dimethylpentanedioic Acid(2dmepdaH2); 3,3-Dimethylpentanedioic acid(3dmepdaH2); X-Ray Crystal Structures; |
| Academic Unit: |
Faculty of Science and Engineering > Chemistry |
| Item ID: |
9717 |
| Depositing User: |
Dr. Malachy McCann
|
| Date Deposited: |
26 Jul 2018 13:51 |
| Journal or Publication Title: |
Bioinorganic Chemistry and Applications |
| Publisher: |
Hindawi Publishing Corporation |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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