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    The subiculum to entorhinal cortex projection is capable of sustaining both short-and long-term plastic changes

    Commins, Sean and Craig, Sarah (2006) The subiculum to entorhinal cortex projection is capable of sustaining both short-and long-term plastic changes. Behavioural Brain Research, 174. pp. 281-288.

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    The hippocampus communicates with the neocortex via the entorhinal cortex. These areas are thought to be critically involved in the consolidation of memories. The hippocampus is considered to be the site of association of sensory information, which is then laid down for long-term storage in the neocortex. We examined the projection from the subiculum to the entorhinal cortex to determine whether it could function to transfer this hippocampally-processed information to the neocortex. Following stimulation in the subiculum we demonstrate a negative-going deflection followed by a positive-going deflection in the entorhinal cortex. This projection is capable of short-term plastic changes in the form of PPF. FIn addition, we demonstrate that long-term synaptic changes in the form of LTP and LTD could be sustained for at least 30 min on this pathway. Finally we show that PPF changes after LTP and LTD, suggesting that a presynaptic mechanism may be involved in both of these pathways.

    Item Type: Article
    Keywords: Long-term potentiation (LTP); Long-term depression;(LTD) Paired-pulse facilitation (PPF); Hippocampus; Subiculum; Entorhinal cortex; Synaptic plasticity; Memory;
    Academic Unit: Faculty of Science and Engineering > Psychology
    Item ID: 978
    Depositing User: Dr. Sean Commins
    Date Deposited: 12 May 2008
    Journal or Publication Title: Behavioural Brain Research
    Publisher: Elsevier
    Refereed: Yes
      Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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