Teles-Grillo Ruivo, Leonor M. and Baker, Keeley L. and Conway, Michael W. and Kinsley, Peter J. and Gilmour, Gary and Phillips, Keith G. and Isaac, John T.R. and Lowry, John P. and Mellor, Jack R. (2017) Coordinated Acetylcholine Release in Prefrontal Cortex and Hippocampus Is Associated with Arousal and Reward on Distinct Timescales. Cell Reports, 18 (4). pp. 905-917.

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Abstract

Cholinergic neurotransmission throughout the neocortex and hippocampus regulates arousal, learning, and attention. However, owing to the poorly characterized timing and location of acetylcholine release, its detailed behavioral functions remain unclear. Using electrochemical biosensors chronically implanted in mice, we made continuous measurements of the spatiotemporal dynamics of acetylcholine release across multiple behavioral states. We found that tonic levels of acetylcholine release were coordinated between the prefrontal cortex and hippocampus and maximal during training on a rewarded working memory task. Tonic release also increased during REM sleep but was contingent on subsequent wakefulness. In contrast, coordinated phasic acetylcholine release occurred only during the memory task and was strongly localized to reward delivery areas without being contingent on trial outcome. These results show that coordinated acetylcholine release between the prefrontal cortex and hippocampus is associated with reward and arousal on distinct timescales, providing dual mechanisms to support learned behavior acquisition during cognitive task performance.

Item Type:	Article
Keywords:	Coordinated Acetylcholine Release; Prefrontal Cortex; Hippocampus; Arousal; Reward; Distinct Timescales;
Academic Unit:	Faculty of Science and Engineering > Chemistry
Item ID:	9913
Depositing User:	John Lowry
Date Deposited:	12 Sep 2018 13:01
Journal or Publication Title:	Cell Reports
Publisher:	Cell Press
Refereed:	Yes
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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