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Montagner, Diego, Fresch, B., Browne, K., Gandin, Valentina and Erxleben, Andrea (2017) A Cu(II) complex targeting the translocator protein: in vitro and in vivo antitumor potential and mechanistic insights. Chemical Communications, 53 (1). pp. 134-137. ISSN 1364-548X
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Abstract
A new Cu-based anticancer metallodrug which targets the translocator protein is reported. [CuBr2(TZ6)] elicits a remarkable in vitro cytotoxicity in sensitive and multidrug resistant cell lines and induces a 98% reduction of tumor mass in a murine tumor model. Target binding was studied by experimental and computational methods.
| Item Type: | Article |
|---|---|
| Keywords: | Cu(II) complex; translocator protein; antitumor potential; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 10753 |
| Identification Number: | 10.1039/C6CC08100B |
| Depositing User: | Diego Montagner |
| Date Deposited: | 26 Apr 2019 14:00 |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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