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Fuku, Xolile, Singh, Baljit, Ajayi, Rachel F., Jijana, Abongile N., Baker, Priscilla, Dempsey, Eithne and Iwuoha, Emmanuel (2015) A gallium telluride quantum dots bioelectrode system for human epidermal growth factor receptor-2 (Her2/neu) oncogene signalling. Analytical Methods, 7 (15). pp. 6114-6124. ISSN 1759-9660
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Abstract
Human epidermal growth factor receptor 2 (Her2/neu) is a biomarker that is overexpressed in human breast cancers. A quantum dots (QDs) -based genosensor for Her2/neu oncogene was developed with gallium telluride QDs and amine-terminated probe ssDNA (NH2-5′-AATTCCAGTGGCCATCAA-3′), that is complementary to the DNA sequence of a section of the ERF gene of HER-2/neu (i.e. 5′-GAACATGAAGGACCGGTGGGC-3′). The QDs were highly crystalline, 6 nm (from XRD) in size and had band gap values of 3.3 eV and 3.5 eV calculated from fluorescence emission and UV-visible absorption data, respectively. The sensor sensitivity and limit of detection values were 10.0 μA ng−1 mL−1 and 0.2 pg mL−1 Her2/neu oncogene, respectively.
| Item Type: | Article |
|---|---|
| Keywords: | Breast Cancer; Immunohistochemistry; Fabrication; Metastasis; Expression; Biomarkers; Pathology; Electrode; Toxicity; Invasion; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 12523 |
| Identification Number: | 10.1039/c5ay00962f |
| Depositing User: | Eithne Dempsey |
| Date Deposited: | 05 Mar 2020 16:51 |
| Journal or Publication Title: | Analytical Methods |
| Publisher: | Royal Society of Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/12523 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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