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Ahmed, Muhib, Rooney, A. Denise, McCann, Malachy, Devereux, Michael, Twamley, Brendan, Milesi Galdino, Anna Clara, Sangenito, Leandro Stefano, Souza, Lucieri Olegario Pereira, Lourenco, Maria Cristina, Gomes, Karen and Santos, Andre L. S. (2019) Synthesis and antimicrobial activity of a phenanthroline-isoniazid hybrid ligand and its Ag+ and Mn2+ complexes. Biometals, 32 (4). pp. 671-682. ISSN 0966-0844
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Abstract
Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag+ and Mn2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1)2]NO3, [Ag(1)2]BF4 and [Mn(1)2](NO3)2. Polymeric {[Ag(1)(NO3)]}n has 1:1 stoichiometry and forms upon infusion of CH2Cl2 into a DMSO solution of [Ag(1)2]NO3. {[Ag(1)(NO3)]}n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage).
| Item Type: | Article |
|---|---|
| Keywords: | 1,10-Phenanthroline; Anti-tuberculosis activity; Antibacterial activity; Antibiotic resistance; Metal complexes; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 13888 |
| Identification Number: | 10.1007/s10534-019-00204-5 |
| Depositing User: | Dr. Denise Rooney |
| Date Deposited: | 01 Feb 2021 13:50 |
| Journal or Publication Title: | Biometals |
| Publisher: | Springer Verlag |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/13888 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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