In this paper, we study the triple top quark production at the future high-energy proton-proton colliders to probe the four-fermion interactions involving three top quarks. We employ the Standard Model Effective Field Theory (SMEFT) to find the upper limits at 95% CL on the Wilson coefficients of these kinds of four-fermion operators. We consider a detailed analysis with a unique signal signature of two same-sign leptons. A full simulation chain includes all the relevant backgrounds, realistic detector simulations, and a cut-based technique are taken into account. This study is presented for the HE-LHC working at the center of mass energy of 27 TeV with 15 ab −1 and FCC-hh working at the center of mass energy of 100 TeV with 30 ab −1 . We show that the future high-energy proton-proton colliders could reach an impressive sensitivity to four-fermion contact interactions involving three top quarks.