This study has discovered key players in Academia, Industry, Government organizations, financial stakeholders and Users of west Ireland that consist of nine counties- Clare, Donegal, Galway, Kerry, Leitrim, Limerick, Mayo, Roscommon and Sligo for developing Regional Innovation Ecosystem focused on Bioeconomy for land and sea. This thesis has explored the mechanisms of Interactions that can contribute towards active collaboration of these four key players such as meetings, webinars etc. that are necessary for knowledge sharing between research centers and Industries for strategic implementation of Bio-economy. Secondary research during the thesis is done using case study analysis of existing regional innovation systems like Agri-food French Bio-economy, Sustainable forest Indicators-National Bioeconomy and Marine Knowledge Exchange Network (M-KEN) in East England. Primary research is conducted through focused interviews of head of the departments of universities, firms, SMEs, NGOs and government organizations of three major sectors: agri-food, forest and fishing of bioeconomy responsible for conducting research, sharing information, making policies and financing the activities. The Data collected through primary and secondary analysis is further used to develop the roadmap of interaction and have provided an analysis of the challenges that exist in implementing west Ireland Bioeconomy for land and Marine.