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Daly, Carmel, Coyle, Seamus, O'Dea, Shirley, O'Driscoll, Lorraine, Daly, Noel, Scanlon, Kevin and Clynes, Martin (1996) mdrl Ribozyme mediated reversal of the multi-drug resistant phenotype in human lung cell lines. Cytotechnology, 19. pp. 199-205. ISSN 0920-9069
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Abstract
An mdrl hammerhead was introduced into two adriamycin-selected multi-drug resistant human lung cell lines both
of which over-express p-glycoprotein. Expression of the ribozyme resulted in a decrease in mdrl mRNA expression
and an increase in drug sensitivity in both cell lines. This would suggest that the use of specific ribozymes may
represent an effective and specific approach in order to restore cellular sensitivity towards anti-cancer drugs.
| Item Type: | Article |
|---|---|
| Keywords: | human lung lines; drug resistance; mdrl; ribozyme; |
| Academic Unit: | Faculty of Science and Engineering > Research Institutes > Human Health Institute |
| Item ID: | 16290 |
| Depositing User: | Dr. Shirley O'Dea |
| Date Deposited: | 12 Jul 2022 12:39 |
| Journal or Publication Title: | Cytotechnology |
| Publisher: | Springer Verlag |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/16290 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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