Since early 2020 the COVID-19 pandemic disrupted societies worldwide. As we moved from expecting the closure of society to be a short-term one to experiencing it as a longer-term phenomenon, we lacked understanding about how the pandemic has affected the working lives and wellbeing of employees in different life and career stages. Drawing from lifespan development approaches and Job Demands-Resources (JD-R), we considered the effect this profound disruption had on stress, burnout, and job satisfaction across career stages over time. We took a multi-level approach to the analysis of three waves of data. Disruptions were a predictor of stress and negatively affected disengagement and job satisfaction over time. We found differences in the ways in which people in different career stages reacted to these disruptions and adjusted over time. Job autonomy positively influenced wellbeing over time, however perceived organizational support contributed to growth in burnout disengagement and exhaustion and lower job satisfaction over time. We discuss the implications of our findings for workplaces managing in the aftermath of external shocks going forward.