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D’Arcy, Kenneth, Schäfer, Tim, De Franco, Michele, Ricco, Raffaele, Gandin, Valentina, Sanz Miguel, Pablo J. and Montagner, Diego (2023) Unusual tellurium(iv) mediated cyclisation diols into dihydroxazoles with potential anticancer activity. New Journal of Chemistry, 47 (39). pp. 18485-18491. ISSN 1144-0546
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Abstract
The role of tellurium in medicinal chemistry has recently grown in importance due to the discovery of the anticancer properties of SAS and AS-101, two inorganic compounds based on Te(IV). Here we describe an unprecedented isolation of a series of tetramethyl-dihydroxazole tellurium hexachloride salts whose structure has been indentified and characterised with several techniques including X-ray crystallography. The novelty resides on the role of tellurium that mediate the cyclisation of 1,1,2,2-tetramethylethylene into duhydroxazole in the presence of nitriles. Reaction mechanism, physiological stability and preliminary cytotoxicity results are discussed.
| Item Type: | Article |
|---|---|
| Keywords: | Anticancer properties; Chemistry; Chemistry; Multidisciplinary; Crystallography; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry Faculty of Science and Engineering > Research Institutes > Human Health Institute |
| Item ID: | 19134 |
| Identification Number: | 10.1039/d3nj03186a |
| Depositing User: | Diego Montagner |
| Date Deposited: | 31 Oct 2024 12:06 |
| Journal or Publication Title: | New Journal of Chemistry |
| Publisher: | Royal Soc Chemistry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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