Globalization is creating challenges which need to be addressed through new thinking. This panel symposium places these challenges at its heart and queries how firms, people and business schools can make a difference, with global leadership and as global leaders. For this panel symposium we have brought together an international group of scholars to engage in a conversation on 1) what firms can do to make a difference with global leadership, 2) what people can do to make a difference as global leaders, and 3) what business schools can do to educate global leaders who will make a difference. Building on current theoretical, conceptual and empirical work the panelists will examine contemporary issues by taking a fresh look at global leadership and querying in what ways global leaders (and global leadership) can make a difference in our world today and tomorrow. The organizers aim to engage the audience in this endeavor.