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    Electrochemical behaviour and DNA intercalation studies of novel antimicrobial Bis - Cu(II) substituted Dipyridophenazine complexes


    Beirne, Darren, O'Neill, Sean, Dempsey, Eithne, Kavanagh, Kevin, Diego, Seamus Montagner and Barrett, Stephen (2025) Electrochemical behaviour and DNA intercalation studies of novel antimicrobial Bis - Cu(II) substituted Dipyridophenazine complexes. Inorganica Chimica Acta, 587 (122829). pp. 1-7. ISSN 0020-1693

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    Abstract

    The public health threat caused by antimicrobial drug resistance has led to research towards alternatives to current chemotherapeutics, with metal-based complexes providing an excellent and promising avenue. Cu(II) species are of particular interest in this area due to their redox properties that could interfere with and inhibit bacterial growth. Here, we report the synthesis and characterisation of four novel bis-Cu(II) substituted Dipyridophenazine complexes. The dypyridophenazine ligands (DPPZ) where synthesized with different substituents at the 11 position (i.e. NO2, Br, CH3 and CN) to evaluate the effect of the functionality with respect the redox and biological behaviour. The DNA intercalation properties together with a detailed electrochemical study of the complexes and of the ligands is reported. The toxicity of the complexes against Methicillin Resistant Staphylococcus aureus (MRSA) and the yeast Candida albicans was characterised and the promise of this family of complexes as novel anti-microbial drugs in a post-antibiotic age was demonstrated.
    Item Type: Article
    Keywords: Copper(II); Dipyridophenazine; DNA intercalation; Redox activity; Antimicrobial;
    Academic Unit: Faculty of Science and Engineering > Chemistry
    Faculty of Science and Engineering > Research Institutes > Human Health Institute
    Item ID: 20158
    Identification Number: 10.1016/j.ica.2025.122829
    Depositing User: IR Editor
    Date Deposited: 03 Jul 2025 12:04
    Journal or Publication Title: Inorganica Chimica Acta
    Publisher: Elsevier
    Refereed: Yes
    Related URLs:
    URI: https://mural.maynoothuniversity.ie/id/eprint/20158
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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