Binge drinking and alcohol-related behaviors have been viewed as major concerns on college campuses. Although national studies were conducted to describe these behaviors, less research attempted to explain them. Self-control theory is extended as a theoretical framework to explain both while considering other known risk factors. Using a sample of college students (n = 268) from a university in the southern United States, the additive and interactive effects of self-control were modeled to predict binge drinking and negative alcohol-related behaviors. A series of multivariate regression models showed that low self-control had effects on binge drinking and related behaviors. Binge drinking's effect on negative alcohol-related behaviors varied across levels of self-control.