There is a growing social demand for educational systems to lead towards more sustainability-informed entrepreneurial education, to help enhance entrepreneurial mindsets. Entrepreneurial education emerges as critical in ensuring the development of academic and professional training that brings sustainability changes to existing business models - integrating the development of sustainability-informed critical thinking, problem-solving and problem-framing skills attune to current and emerging business challenges. To help prepare future entrepreneurs, this paper explores the traditional knowledge practices of the entrepreneurial mindset and the importance of identifying alternative approaches to reduce the disconnection between traditional learning theories, educational systems and models that allow entrepreneurs to innovate, and to respond to the business demand for sustainability-informed teaching and learning practices. The essential roles of entrepreneurs and the paths of their mindset development are explored to help unfold their potential to support and develop sustainability-informed entrepreneurship.