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    Beyond the QT interval: how QT/RR hysteresis may reveal a sex-dependent hidden risk for cardiac arrhythmias


    Banks, Nile, Robinson, Austin T., Wray, D. Walter and Bunsawat, Kanokwan (2025) Beyond the QT interval: how QT/RR hysteresis may reveal a sex-dependent hidden risk for cardiac arrhythmias. American Journal of Physiology-Heart and Circulatory Physiology, 329 (4). H1006-H1009. ISSN 0363-6135

    Abstract

    Cardiac arrhythmia is a life-threatening condition in which disturbances in the electrical signals that control the heart cause an irregular heart rate (HR) or rhythm that may lead toa sudden cessation of cardiac activity and potentiate sudden cardiac death (SCD) (1). Cardiac arrhythmia can be categorized into two subtypes: supraventricular arrhythmias (atrial fibrillation, atrial flutter, and paroxysmal supra ventriculartachy cardia) and ventricular arrhythmias (ventricular tachy-cardia and ventricular fibrillation) (1). Ventricular arrhythmias are the more serious form that occur most frequently in the context of heart disease, although the incidence is increasing in apparently healthy individuals (2). The age- and sex-adjusted rates of idiopathic ventricular arrhythmias increased from 45 to 62 per 100,000 individuals from 2005–2007 to 2011–2013, with an overall incidence increasing with age (2). Thus, identification of potential prognostic bio-markers is important clinically and may aid in the risk stratification and prevention of cardiac arrhythmias and SCD in the general population, regardless of heart disease.
    Item Type: Article
    Keywords: QT interval; QT/RR hysteresis; sex-dependent hidden risk; cardiac arrhythmias;
    Academic Unit: Faculty of Science and Engineering > Sports Science and Nutrition
    Item ID: 21246
    Identification Number: 10.1152/ajpheart.00699.2025
    Depositing User: Nile Banks
    Date Deposited: 26 Feb 2026 14:46
    Journal or Publication Title: American Journal of Physiology-Heart and Circulatory Physiology
    Publisher: American Physiological Society
    Refereed: Yes
    Related URLs:
    Use Licence: This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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