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Singh, Ishwar, Vyle, Joseph S. and Heaney, Frances (2009) Fast, copper-free click chemistry: a convenient solid-phase approach to oligonucleotide conjugation. Chemical Communications (22). pp. 3276-3278. ISSN 1359-7345
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Abstract
Solid-phase oligonucleotide conjugation by nitrile oxide–alkyne
click cycloaddition chemistry has been successfully demonstrated;
the reaction, compatible with all nucleobases, requires
no metal catalyst and proceeds under physiological conditions.
| Item Type: | Article |
|---|---|
| Additional Information: | © Royal Society of Chemistry 2009 |
| Keywords: | copper-free click chemistry; solid-phase; oligonucleotide conjugation; catalyst; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 2706 |
| Identification Number: | DOI: 10.1039/B904185K |
| Depositing User: | Dr. Frances Heaney |
| Date Deposited: | 14 Sep 2011 13:53 |
| Journal or Publication Title: | Chemical Communications |
| Publisher: | Royal Society of Chemstry |
| Refereed: | Yes |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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