Coogan, Andrew, Schutova, Barbora, Husung, Susanne, Furczyk, Karolina, Baune, Bernhard T., Kropp, Peter, Hassler, Frank and Thome, Johannes (2012) The Circadian System in Alzheimer’s Disease: Disturbances, Mechanisms, and Opportunities. Biological Psychiatry, In press, corrected proof. pp. 1-7. ISSN 0006-3223
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Abstract
Alzheimer’s disease (AD) is a devastating neurodegenerative condition associated with severe cognitive and behavioral impairments.
Circadian rhythms are recurring cycles that display periods of approximately 24 hours and are driven by an endogenous circadian
timekeeping system centered on the suprachiasmatic nucleus of the hypothalamus. We review the compelling evidence that circadian
rhythms are significantly disturbed in AD and that such disturbance is of significant clinical importance in terms of behavioral
symptoms. We also detail findings from neuropathological studies of brain areas associated with the circadian system in postmortem
studies, the use of animal models of AD in the investigation of circadian processes, and the evidence that chronotherapeutic
approaches aimed at bolstering weakened circadian rhythms in AD produce beneficial outcomes. We argue that further investigation in
such areas is warranted and highlight areas for future research that might prove fruitful in ultimately providing new treatment options
for this most serious and intractable of conditions.
Item Type: | Article |
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Additional Information: | The in press version of this article also available at http://dx.doi.org/10.1016/j.biopsych.2012.11.021 |
Keywords: | Alzheimer’s disease; chronotherapy; circadian; dementia; SCN; sleep; |
Academic Unit: | Faculty of Science and Engineering > Psychology |
Item ID: | 4234 |
Depositing User: | Dr. Andrew Coogan |
Date Deposited: | 05 Mar 2013 16:26 |
Journal or Publication Title: | Biological Psychiatry |
Publisher: | Elsevier |
Refereed: | Yes |
Related URLs: | |
URI: | https://mural.maynoothuniversity.ie/id/eprint/4234 |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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