Organizations in the Digital era are facing unprecedented challenges to leverage emerging technologies and reshape their industries in response to contemporary challenges. Human-Centred Design (HCD) represents a way that organizations can rethink and restructure themselves to ensure they are optimized to adapt to the emerging Digital challenges. This white paper defines Human-Centred Design (HCD) and provides some historical context for how we define technology and how this has affected the design process to date. This is followed by a more detailed description of HCD concepts and processes. Finally, this paper describes other areas in which HCD can be used to support Digital transformation.