García, Míriam R., Pearlmutter, Barak A., Wellstead, Peter E. and Middleton, Richard H. (2013) A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation. PLoS ONE, 8 (9). e73456. ISSN 1932-6203
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Abstract
Parkinsonian and essential tremor can often be effectively treated by deep brain stimulation. We propose a novel
explanation for the mechanism by which this technique ameliorates tremor: a reduction of the delay in the relevant motor
control loops via preferential antidromic blockade of slow axons. The antidromic blockade is preferential because the pulses
more rapidly clear fast axons, and the distribution of axonal diameters, and therefore velocities, in the involved tracts, is
sufficiently long-tailed to make this effect quite significant. The preferential blockade of slow axons, combined with gain
adaptation, results in a reduction of the mean delay in the motor control loop, which serves to stabilize the feedback
system, thus ameliorating tremor. This theory, without any tuning, accounts for several previously perplexing phenomena,
and makes a variety of novel predictions.
Item Type: | Article |
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Additional Information: | © 2013 García et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. **13 Aug 2014: The PLOS ONE Staff (2014) Correction: A Slow Axon Antidromic Blockade Hypothesis for Tremor Reduction via Deep Brain Stimulation. PLoS ONE 9(8): e106145. doi: 10.1371/journal.pone.0106145 |
Keywords: | Slow Axon Antidromic Blockade Hypothesis; Tremor Reduction; Deep Brain Stimulation; |
Academic Unit: | Faculty of Science and Engineering > Computer Science |
Item ID: | 6546 |
Identification Number: | 10.1371/journal.pone.0073456 |
Depositing User: | Barak Pearlmutter |
Date Deposited: | 09 Nov 2015 16:43 |
Journal or Publication Title: | PLoS ONE |
Publisher: | Public Library of Science |
Refereed: | Yes |
Funders: | Science Foundation Ireland (SFI) |
Related URLs: | |
URI: | https://mural.maynoothuniversity.ie/id/eprint/6546 |
Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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