The ability of climate models to simulate large-scale temperature changes during the twentieth century when they include both anthropogenic and natural forcings and their inability to account for warming over the last 50 yr when they exclude increasing greenhouse gas concentrations has been used as evidence for an anthropogenic influence on global warming. One criticism of the models used in many of these studies is that they exclude some forcings of potential importance, notably from fossil fuel black carbon, biomass smoke, and land use changes. Herein transient simulations with a new model, the Hadley Centre Global Environmental Model version 1 (HadGEM1), are described, which include these forcings in addition to other anthropogenic and natural forcings, and a fully interactive treatment of atmospheric sulfur and its effects on clouds. These new simulations support previous work by showing that there was a significant anthropogenic influence on near-surface temperature change over the last century. They demonstrate that black carbon and land use changes are relatively unimportant for explaining global mean near-surface temperature changes. The pattern of warming in the troposphere and cooling in the stratosphere that has been observed in radiosonde data since 1958 can only be reproduced when the model includes anthropogenic forcings. However, there are some discrepancies between the model simulations and radiosonde data, which are largest where observational uncertainty is greatest in the Tropics and high latitudes. Predictions of future warming have also been made using the new model. Twenty-first-century warming rates, following policy-relevant emissions scenarios, are slightly greater in HadGEM1 than in the Third Hadley Centre Coupled Ocean–Atmosphere General Circulation Model (HadCM3) as a result of the extra forcing in HadGEM1. An experiment in which greenhouse gases and other anthropogenic forcings are stabilized at 2100 levels and held constant until 2200 predicts a committed twenty-second-century warming of less than 1 K, whose spatial distribution resembles that of warming during the twenty-first century, implying that the local feedbacks that determine the pattern of warming do not change significantly.