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Murphy, John J., Quintard, Adrien, McArdle, Patrick, Alexakis, Alexandre and Stephens, John C. (2011) Asymmetric Organocatalytic 1,6-Conjugate Addition of Aldehydes to Dienic Sulfones. Angewandte Chemie International Edition, 50 (22). pp. 5095-5098. ISSN 1521-3773
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Abstract
An unprecedented 1,6-enamine conjugate addition exploiting the charge delocalization in 1,3-bis(sulfonyl) butadienes has been developed. By appropriately designing a Michael acceptor, unique reactivities were obtained for the formation of highly valuable dienes containing two versatile vinyl sulfones (see scheme, TMS=trimethylsilyl).
| Item Type: | Article |
|---|---|
| Additional Information: | We thank the Irish Research Council for Science, Engineering & Technology (IRCSET) and NUI Maynooth for funding.We also thank Dr. Padraig McLoughlin of Teagasc and the Ashtown Food Research Centre, Dublin for some NMR analysis. |
| Keywords: | asymmetric synthesis; conjugate addition; dienes; organocatalysis; sulfones; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 7705 |
| Identification Number: | 10.1002/anie.201100804 |
| Depositing User: | Dr John Stephens |
| Date Deposited: | 10 Jan 2017 15:07 |
| Journal or Publication Title: | Angewandte Chemie International Edition |
| Publisher: | Wiley |
| Refereed: | Yes |
| Funders: | Irish Research Council for Science Engineering and Technology (IRCSET) |
| Related URLs: | |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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