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O'Neill, Robert D., Rocchitta, Gaia, McMahon, Colm P., Serra, Pier A. and Lowry, John P. (2008) Designing sensitive and selective polymer/enzyme composite biosensors for brain monitoring in vivo. TrAC Trends in Analytical Chemistry, 27 (1). pp. 78-88. ISSN 0165-9936
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Abstract
Amperometric polymer/enzyme composite (PEC) biosensors, incorporating a poly(o-phenylenediamine) ultra-thin permselective barrier, possess a variety of characteristics that make them suitable for monitoring brain energy and neurotransmitter dynamics in vivo. This review highlights PEC sensitivity and selectivity parameters, which allow development of the basic design in a systematic way in order to improve their performance and to diversify the analyte range of these novel probes of brain function.
| Item Type: | Article |
|---|---|
| Keywords: | Ascorbic acid interference; Brain monitoring; Electropolymerization; Glucose; Glutamate; H2O2 permeability; Polymer-modified electrode; |
| Academic Unit: | Faculty of Science and Engineering > Chemistry |
| Item ID: | 8034 |
| Identification Number: | 10.1016/j.trac.2007.11.008 |
| Depositing User: | John Lowry |
| Date Deposited: | 21 Mar 2017 16:20 |
| Journal or Publication Title: | TrAC Trends in Analytical Chemistry |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Funders: | Science Foundation Ireland (SFI), Health Research Board (HRB) |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/8034 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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