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    [Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities


    Curran, Robert and Lenehan, Joanne and McCann, Malachy and Kavanagh, Kevin and Devereux, Michael and Egan, Denise A. and Clifford, Grace and Keane, Kevin and Creaven, Bernadette S. and McKee, Vickie (2007) [Ag2(aca)2]n and [Ag4(aca)4(NH3)2] (acaH = 9-anthracenecarboxylic acid): Synthesis, X-ray crystal structures, antimicrobial and anti-cancer activities. Inorganic Chemistry Communications, 10 (10). pp. 1149-1153. ISSN 1387-7003

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    Abstract

    [Ag2(9-aca)2]n and [Ag4(9-aca)4(NH3)2] (9-acaH = 9-anthracenecarboxylic acid) have been prepared and structurally characterized. [Ag2(9-aca)2]n consists of polymeric ribbons of linked disilver(I) syn–syn bridged dicarboxylate units. [Ag4(9-aca)4(NH3)2] is tetrameric and centrosymmetric, with two syn–syn bridging carboxylates linked to the bimetallic Ag–Ag core and a further two syn–anti bridged carboxylate ligands in the equatorial plane, being coordinated to one Ag in the bimetallic core and to a second Ag, with the latter also bonded to an NH3 ligand. In vitro studies show that both complexes are extremely cytotoxic against selected human fungal and bacterial pathogens, and each complex also greatly inhibits the growth of two mammalian cancer cell lines.

    Item Type: Article
    Keywords: 9-Anthracenecarboxylic acid; X-ray structure; Silver(I); Anti-fungal; Anti-bacterial; Anti-cancer;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 11117
    Identification Number: https://doi.org/10.1016/j.inoche.2007.06.021
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 01 Oct 2019 15:46
    Journal or Publication Title: Inorganic Chemistry Communications
    Publisher: Elsevier
    Refereed: Yes
    URI:

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