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    Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates


    Martin, Harlei and McGovern, Mairead and Abbey, Lorna and Gilroy, Aisling and Mullins, Stephanie and Howell, Sarah and Kevin, Kavanagh and Velasco-Torrijos, Trinidad (2018) Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates. European Journal of Medicinal Chemistry, 160. pp. 82-93. ISSN 0223-5234

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    Abstract

    The yeast Candida albicans is an opportunistic fungal pathogen which induces superficial and systemic infections in immunocompromised patients. Adherence to host tissue is critical to its ability to colonise and infect the host. The work presented here describes the synthesis of a small library of aromatic glycoconjugates (AGCs) and their evaluation as inhibitors of C. albicans adherence to exfoliated buccal epithelial cells (BECs). We identified a divalent galactoside, ligand 2a, capable of displacing over 50% of yeast cells already attached to the BECs. Fluorescence imaging indicates that 2a may bind to structural components of the fungal cell wall.

    Item Type: Article
    Keywords: Candida albicans; Anti-Adherence; Multivalent glycoconjugates; Structure-activity relationship study; Copper-catalyzed azide-alkyne cycloaddition (CuAAC);
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12436
    Identification Number: https://doi.org/10.1016/j.ejmech.2018.10.011
    Depositing User: Dr. Trinidad Velasco-Torrijos
    Date Deposited: 17 Feb 2020 16:44
    Journal or Publication Title: European Journal of Medicinal Chemistry
    Publisher: Elsevier
    Refereed: Yes
    URI:

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