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Martin, Harlei, McGovern, Mairead, Abbey, Lorna, Gilroy, Aisling, Mullins, Stephanie, Howell, Sarah, Kavanagh, Kevin and Velasco-Torrijos, Trinidad (2018) Inhibition of adherence of the yeast Candida albicans to buccal epithelial cells by synthetic aromatic glycoconjugates. European Journal of Medicinal Chemistry, 160. pp. 82-93. ISSN 0223-5234
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Abstract
The yeast Candida albicans is an opportunistic fungal pathogen which induces superficial and systemic
infections in immunocompromised patients. Adherence to host tissue is critical to its ability to colonise
and infect the host. The work presented here describes the synthesis of a small library of aromatic
glycoconjugates (AGCs) and their evaluation as inhibitors of C. albicans adherence to exfoliated buccal
epithelial cells (BECs). We identified a divalent galactoside, ligand 2a, capable of displacing over 50% of
yeast cells already attached to the BECs. Fluorescence imaging indicates that 2a may bind to structural
components of the fungal cell wall.
| Item Type: | Article |
|---|---|
| Keywords: | Candida albicans; Anti-Adherence; Multivalent glycoconjugates; Structure-activity relationship study; Copper-catalyzed azide-alkyne cycloaddition (CuAAC); |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 12436 |
| Identification Number: | 10.1016/j.ejmech.2018.10.011 |
| Depositing User: | Dr. Trinidad Velasco-Torrijos |
| Date Deposited: | 17 Feb 2020 16:44 |
| Journal or Publication Title: | European Journal of Medicinal Chemistry |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/12436 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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