Masterson, Joanne C. and Furuta, Glenn T. and Lee, James J.
(2011)
Update on clinical and immunological features of eosinophilic
gastrointestinal diseases.
Current Opinion in Gastroenterology, 27 (6).
pp. 515-522.
ISSN 1531-7056
Abstract
Purpose of review—Eosinophilic gastrointestinal diseases (EGIDs) are an increasingly
common heterogeneous group of intestinal diseases. The purpose of this review is to present the
latest developments in the care of patients with EGIDs and to summarize a growing literature
defining the clinical features and mechanistic elements of eosinophils and their complex
relationships with the gastrointestinal tract.
Recent findings—Recent studies continue to define what constitutes ‘normal’ and ‘abnormal’
numbers of eosinophils in the different sections of the gastrointestinal tract. Symptom complexes
of EGIDs appear to be related primarily to the mucosal, as opposed to the muscular or serosal,
forms of EGIDs. Dissection of the mucosal microenvironment is uncovering a complex array of
cells, other than eosinophils, that likely contribute to the inflammatory response associated with
EGIDs. Mechanistic studies have identified genetic perturbations (eotaxin-3, thymic stromal
lymphopoietin, IL-13, and filaggrin) that may also contribute to the development of the most often
encountered and well studied EGID, eosinophilic esophagitis.
Summary—Clinicians should remain aware of EGIDs as a diagnostic possibility for patients
with common gastrointestinal symptoms. Additional research is needed to determine mechanistic
processes leading to dysfunction associated with eosinophilic gastrointestinal inflammation.
| Item Type: |
Article
|
| Keywords: |
eosinophilic esophagitis; eotaxin; filaggrin; mucosa; thymic stromal lymphopoetin; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
12498 |
| Identification Number: |
https://doi.org/10.1097/MOG.0b013e32834b314c |
| Depositing User: |
Joanne Masterson
|
| Date Deposited: |
27 Feb 2020 15:55 |
| Journal or Publication Title: |
Current Opinion in Gastroenterology |
| Publisher: |
Lippincott, Williams & Wilkins |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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