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    IL-10 interferes directly with TCR-induced IFN-c but not IL-17 production in memory T cells.


    Naundorf, Sandra and Schroeder, Martina and Hoflich, Conny and Nimisha, Suman and Hans-Dieter, Volk and Grutz, Gerald (2009) IL-10 interferes directly with TCR-induced IFN-c but not IL-17 production in memory T cells. European Journal of Immunology, 39. pp. 1066-1077. ISSN 1521-4141

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    Abstract

    IL-10 is a potent immunoregulatory and anti-inflammatory cytokine. However, therapeutic trials in chronic inflammation have been largely disappointing. It is well established that IL-10 can inhibit Th1 and Th2 cytokine production via indirect effects on APC. Less data are available about the influence of IL-10 on IL-17 production, a cytokine which has been recently linked to chronic inflammation. Furthermore, there are only few reports about a direct effect of IL-10 on T cells. We demonstrate here that IL-10 can directly interfere with TCR-induced IFN-c production in freshly isolated memory T cells in the absence of APC. This effect was independent of the previously described effects of IL-10 on T cells, namely inhibition of IL-2 production and inhibition of CD28 signaling. In contrast, IL-10 did not affect anti-CD3/anti-CD28-induced IL-17 production from memory T cells even in the presence of APC. This might have implications for the interpretation of therapeutic trials in patients with chronic inflammation where Th17 cells contribute to pathogenesis.

    Item Type: Article
    Keywords: Cytokine; IFN-y; IL-10; IL-17; T cells;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 12662
    Identification Number: https://doi.org/10.1002/eji.20083877
    Depositing User: Martina Schroeder
    Date Deposited: 30 Mar 2020 10:41
    Journal or Publication Title: European Journal of Immunology
    Publisher: Wiley-VCH Verlag
    Refereed: Yes
    URI:

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