MURAL - Maynooth University Research Archive Library



    Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach


    Oyarzun, Diego and Ingalls, Brian and Kalamatianos, Dimitrios (2007) Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach. Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007 . pp. 491-496.

    [img] Download (309kB)


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthetical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time-optimal control.

    Item Type: Article
    Keywords: Metabolic pathways; metabolic regulation; optimal control;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 2119
    Depositing User: Dimitris Kalamatianos
    Date Deposited: 22 Sep 2010 15:26
    Journal or Publication Title: Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007
    Refereed: Yes
    URI:

      Repository Staff Only(login required)

      View Item Item control page

      Downloads

      Downloads per month over past year