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Oyarzun, Diego, Ingalls, Brian and Kalamatianos, Dimitrios (2007) Optimal metabolic regulation by temporal variation of enzyme activities: a control theoretic approach. Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007. pp. 491-496.
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Abstract
In this paper we use an optimal control approach to analyze time dependent enzyme concentrations that minimize the transition time of a metabolic pathway while respecting the natural constraints imposed by a limited biosynthetical capacity. Our main result states that, under appropriate assumptions, at each time instant all the available enzyme production capacity is allocated to a single reaction, a finding reminiscent of bang-bang control laws typical in classical time-optimal control.
| Item Type: | Article |
|---|---|
| Keywords: | Metabolic pathways; metabolic regulation; optimal control; |
| Academic Unit: | Faculty of Science and Engineering > Research Institutes > Hamilton Institute |
| Item ID: | 2119 |
| Depositing User: | Dimitris Kalamatianos |
| Date Deposited: | 22 Sep 2010 15:26 |
| Journal or Publication Title: | Proceedings of the Foundations of Systems Biology in Engineering Conference, Stuttgart, Germany. FOSBE 2007 |
| Refereed: | Yes |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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