MURAL - Maynooth University Research Archive Library



    On-line estimation in a distributed parameter bioreactor: Application to the Gluconic Acid production


    García, Míriam R. and Vilas, Carlos and Balsa-Canto, Eva and Lyubenova, Velislava N. and Ignatova, Maya N. and Alonso, Antonio A. (2011) On-line estimation in a distributed parameter bioreactor: Application to the Gluconic Acid production. Computers & Chemical Engineering, 35 (1). ISSN 0098-1354

    [img] Download (1MB)


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    This work presents a methodology which exploits the underlying biochemical structure of bioprocesses to estimate concentrations in aerobic fermenters from oxygen measurements. Although a number of estimators have been proposed over the years in the literature, the methodology proposed in this work is able to operate in transient conditions while does not require the knowledge of the growth kinetics. In addition, it can be also applied to fermenters where the spatial distribution of the concentrations is relevant. In this case, we propose a systematic approach to optimally locate the sensors based on the use of reduced order models. This method allows the reconstruction of the oxygen concentrations from a limited number of sensors. Finally, the methodology proposed will be illustrated on a horizontal tubular reactor for the production of gluconic acid by free-growth of Aspergillus niger.

    Item Type: Article
    Additional Information: Preprint version of original published article. The definitive version of this article is available from http://www.sciencedirect.com/ at DOI: http://dx.doi.org/10.1016/j.compchemeng.2010.05.005
    Keywords: On-line indirect estimation; Aerobic Fermentation; Tubular (Bio)Reactors; Optimal sensor location;
    Academic Unit: Faculty of Science and Engineering > Research Institutes > Hamilton Institute
    Item ID: 3625
    Depositing User: Miriam Garcia
    Date Deposited: 01 May 2012 15:29
    Journal or Publication Title: Computers & Chemical Engineering
    Publisher: Elsevier
    Refereed: No
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year