MURAL - Maynooth University Research Archive Library



    'Silver bullets' in antimicrobial chemotherapy: Synthesis, characterisation and biological screening of some new Ag(I)-containing imidazole complexes


    Rowan, Raymond and Tallon, Theresa M. and Sheahan, Anita and Curran, Robert and McCann, Malachy and Kavanagh, Kevin and Devereux, Michael and McKee, Vickie (2006) 'Silver bullets' in antimicrobial chemotherapy: Synthesis, characterisation and biological screening of some new Ag(I)-containing imidazole complexes. Polyhedron, 25. pp. 1771-1778. ISSN 0277-5387

    [img]
    Preview
    Download (235kB) | Preview


    Share your research

    Twitter Facebook LinkedIn GooglePlus Email more...



    Add this article to your Mendeley library


    Abstract

    Simple synthetic routes are given to the Ag(I) complexes, [Ag2(imH)4](salH)2 (imH = imidazole; salH2 = salicylic acid), [Ag(MeNO2imH)2]ClO4 · nH2O (MeNO2imH = 2-methyl-5-nitroimidazole; n = 1, 3), [Ag(NO2im)] (NO2imH = 5-nitroimidazole) and [Ag(apim)]ClO4 (apim = 1-(3-aminopropyl)imidazole). X-ray crystal structures of [Ag2(imH)4](salH)2, [Ag(MeNO2imH)2]ClO4 · H2O and [Ag(apim)]ClO4 were obtained. The new Ag(I) complexes and related known Ag(I) imidazolates were screened for their growth inhibitory effects (in vitro) against the pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli and also the fungal pathogen Candida albicans. [Ag2(imH)4](salH)2, in comparison to the prescription drug silver sulfadiazine, had significantly better anti-bacterial qualities, whilst against the fungus C. albicans it was 47 times more potent than the marketed drug ketoconazole.

    Item Type: Article
    Keywords: Imidazoles; X-ray structures; Silver(I); Anti-fungal; Anti-bacterial;
    Academic Unit: Faculty of Science and Engineering > Biology
    Item ID: 7575
    Identification Number: https://doi.org/10.1016/j.poly.2005.11.021
    Depositing User: Dr. Kevin Kavanagh
    Date Deposited: 26 Oct 2016 13:48
    Journal or Publication Title: Polyhedron
    Publisher: Elsevier
    Refereed: Yes
    Funders: Higher Education Authority (HEA), Kildare County Council
    URI:

    Repository Staff Only(login required)

    View Item Item control page

    Downloads

    Downloads per month over past year