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Rowan, Raymond, Tallon, Theresa M., Sheahan, Anita, Curran, Robert, McCann, Malachy, Kavanagh, Kevin, Devereux, Michael and McKee, Vickie (2006) 'Silver bullets' in antimicrobial chemotherapy: Synthesis, characterisation and biological screening of some new Ag(I)-containing imidazole complexes. Polyhedron, 25. pp. 1771-1778. ISSN 0277-5387
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Abstract
Simple synthetic routes are given to the Ag(I) complexes, [Ag2(imH)4](salH)2 (imH = imidazole; salH2 = salicylic acid), [Ag(MeNO2imH)2]ClO4 · nH2O (MeNO2imH = 2-methyl-5-nitroimidazole; n = 1, 3), [Ag(NO2im)] (NO2imH = 5-nitroimidazole) and [Ag(apim)]ClO4 (apim = 1-(3-aminopropyl)imidazole). X-ray crystal structures of [Ag2(imH)4](salH)2, [Ag(MeNO2imH)2]ClO4 · H2O and [Ag(apim)]ClO4 were obtained. The new Ag(I) complexes and related known Ag(I) imidazolates were screened for their growth inhibitory effects (in vitro) against the pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli and also the fungal pathogen Candida albicans. [Ag2(imH)4](salH)2, in comparison to the prescription drug silver sulfadiazine, had significantly better anti-bacterial qualities, whilst against the fungus C. albicans it was 47 times more potent than the marketed drug ketoconazole.
| Item Type: | Article |
|---|---|
| Keywords: | Imidazoles; X-ray structures; Silver(I); Anti-fungal; Anti-bacterial; |
| Academic Unit: | Faculty of Science and Engineering > Biology |
| Item ID: | 7575 |
| Identification Number: | 10.1016/j.poly.2005.11.021 |
| Depositing User: | Dr. Kevin Kavanagh |
| Date Deposited: | 26 Oct 2016 13:48 |
| Journal or Publication Title: | Polyhedron |
| Publisher: | Elsevier |
| Refereed: | Yes |
| Funders: | Higher Education Authority (HEA), Kildare County Council |
| Related URLs: | |
| URI: | https://mural.maynoothuniversity.ie/id/eprint/7575 |
| Use Licence: | This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here |
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