Kerr, Laura and Domijan, Katarina and Cullen, Ivor and Hennelly, Bryan M. (2014) Applications of Raman spectroscopy to the urinary bladder for cancer diagnostics. Photonics and Lasers in Medicine, 3 (3). pp. 193-224. ISSN 2193-0643

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Abstract

Biomolecular changes associated with cancer progression can be identified using Raman spectroscopy, allowing for this technique to be utilized as a non-invasive tool for the diagnosis of bladder cancer. Applications of Raman spectroscopy for diagnostics in real-time have consistently produced higher sensitivities and specificities than current clinical methods. This technique can be applied in vivo during bladder visualization (cystoscopic) procedures as an “optical biopsy” or in vitro to cells obtained from urine cytology specimens. This review follows the evolution of studies in this field from the first in vitro experiment to the most recent in vivo application, identifies how diagnostic algorithms are developed, and provides molecular information associated with the etiology of the biochemical continuum of disease progression. Future prospects for the application of Raman spectroscopy in bladder cancer diagnostics are also discussed.

Item Type:	Article
Additional Information:	Cite as: Kerr, L., Domijan, K., Cullen, I., et al. (2014). Applications of Raman spectroscopy to the urinary bladder for cancer diagnostics. Photonics & Lasers in Medicine, 3(3), pp. 193-224.
Keywords:	Raman microspectroscopy; bladder; cancer diagnostics; Raman fiber-optic probe;
Academic Unit:	Faculty of Science and Engineering > Computer Science Faculty of Science and Engineering > Electronic Engineering Faculty of Science and Engineering > Mathematics and Statistics Faculty of Science and Engineering > Research Institutes > Hamilton Institute
Item ID:	10014
Identification Number:	https://doi.org/10.1515/plm-2014-0004
Depositing User:	Katarina Domijan
Date Deposited:	27 Sep 2018 13:53
Journal or Publication Title:	Photonics and Lasers in Medicine
Publisher:	de Gruyter
Refereed:	Yes
URI:	https://www.degruyter.com/
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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