Carty, Fiona and Mahon, Bernard P. and English, Karen
(2017)
The influence of macrophages on mesenchymal stromal cell therapy:
passive or aggressive agents?
Clinical and Experimental Immunology, 188.
pp. 1-11.
ISSN 1365-2249
Abstract
Mesenchymal stromal cells (MSC) have emerged as promising cell therapies
for multiple conditions based on demonstrations of their potent
immunomodulatory and regenerative capacities in models of inflammatory
disease. Understanding the effects of MSC on T cells has dominated the
majority of work carried out in this field to date; recently, however, a
number of studies have shown that the therapeutic effect of MSC requires
the presence of macrophages. It is timely to review the mechanisms and
manner by which MSC modulate macrophage populations in order to
design more effective MSC therapies and clinical studies. A complex crosstalk
exists through which MSC and macrophages communicate, a
communication that is not controlled exclusively by MSC. Here, we
examine the evidence that suggests that MSC not only respond to
inflammatory macrophages and adjust their secretome accordingly, but also
that macrophages respond to encounters with MSC, creating a feedback
loop which contributes to the immune regulation observed following MSC
therapy. Future studies examining the effects of MSC on macrophages
should consider the antagonistic role that macrophages play in this
exchange.
| Item Type: |
Article
|
| Keywords: |
inflammation; macrophage; mesenchymal stem cells; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
10577 |
| Identification Number: |
https://doi.org/10.1111/cei.12929 |
| Depositing User: |
Karen English
|
| Date Deposited: |
25 Feb 2019 11:39 |
| Journal or Publication Title: |
Clinical and Experimental Immunology |
| Publisher: |
Wiley |
| Refereed: |
Yes |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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