English, Karen and Wood, Kathryn J. (2013) Mesenchymal Stromal Cells in Transplantation Rejection and Tolerance. Cold Spring Harbor perspectives in medicine, 3. ISSN 2157-1422

Preview

Download (617kB) | Preview

Abstract

Mesenchymal stromal cells (MSCs) have recently emerged as promising candidates for cell-based immunotherapy in solid organ transplantation (SOT). In addition to immune modu-lation, MSCs possessproreparative propertiesand preclinical studies indicatethat MSCs havethe capacity to prolong graft survival and in some cases induce tolerance. Currently, theapplication of MSCs in SOT is being evaluated in phase I/II clinical trials. Whereas themechanisms of action used by MSC immunomodulation have been somewhat elucidatedin vitro, the data from preclinical transplant models have been unclear. Furthermore, theoptimal timing, dose,and routeof administration remain tobe elucidated.Importantly, MSCshave the ability to sense their environment, which may influence their function. In thisarticle, we discuss the impact of the local microenvironment on MSCs and the mechanismsof MSC immunomodulation in the setting of SOT.

Item Type:	Article
Keywords:	Mesenchymal Stromal Cells; Transplantation Rejection; Tolerance;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	10583
Identification Number:	https://doi.org/10.1101/cshperspect.a015560
Depositing User:	Karen English
Date Deposited:	25 Feb 2019 14:40
Journal or Publication Title:	Cold Spring Harbor perspectives in medicine
Refereed:	Yes
URI:	Publisher
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

Repository Staff Only(login required)

Item control page

Downloads

Origin of downloads