McNamee, Eóin N. (2019) Neutrophil-derived microRNAs put the (DNA) breaks on intestinal mucosal healing. Journal of Clinical Investigation, 129 (2). pp. 499-502. ISSN 1558-8238

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Abstract

A predominant feature of intestinal inflammation is the accumulation of neutrophils, which dictates a fine balance between epithelial repair or progression to chronic inflammation. While the processes of mucosal healing are well studied, how neutrophils advance an inflammatory insult towards epithelial neoplasia is less understood. In this issue of the JCI, Butin-Israeli et al. outline a mechanism whereby neutrophils control epithelial fitness and genomic instability via delivery of miR-23a–and miR-155–containing microparticles. Localized delivery of antisense oligonucleotides targeting miR-23a and miR-155 reversed this genomic instability and accelerated mucosal healing. This mechanism of neutrophil-derived microRNA shuttling opens up new therapeutic potential to enhance epithelial healing and limit mucosal injury.

Item Type:	Article
Keywords:	Neutrophil-derived microRNAs; intestinal mucosal healing; intestinal inflammation;
Academic Unit:	Faculty of Science and Engineering > Biology
Item ID:	10934
Identification Number:	https://doi.org/10.1172/JCI125779
Depositing User:	Eoin McNamee
Date Deposited:	11 Jul 2019 14:19
Journal or Publication Title:	Journal of Clinical Investigation
Publisher:	American Society for Clinical Investigation
Refereed:	Yes
URI:
Use Licence:	This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available here

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