Dissmeyer, Nico and Rivas, Susana and Graciet, Emmanuelle
(2018)
Life and death of proteins after protease cleavage: protein degradation by the N-end rule pathway.
New Phytologist, 218 (3).
pp. 929-935.
ISSN 0028-646X
Abstract
The activity and abundance of proteins within a cell are controlled precisely to
ensure the regulation of cellular and physiological processes. In eukaryotes, this
can be achieved by targeting specific proteins for degradation by the ubiquitinproteasome
system. The N-end rule pathway, a subset of the ubiquitinproteasome
system, targets proteins for degradation depending on the identity of
a protein N-terminal residue or its post-translational modifications. Here, we
discuss the most recent findings on the diversity of N-end rule pathways. We also
focus on recently found defensive functions of the N-end rule pathway in plants.
We then discuss the current understanding of N-end rule substrate formation by
protease cleavage. Finally, we review state-of-the-art proteomics techniques used
for N-end rule substrate identification, and discuss their usefulness and
limitations for the discovery of the molecular mechanisms underlying the roles of
the N-end rule pathway in plants.
| Item Type: |
Article
|
| Additional Information: |
© 2017 The Authors. Cite as: Dissmeyer, N. , Rivas, S. and Graciet, E. (2018), Life and death of proteins after protease cleavage: protein degradation by the N‐end rule pathway. New Phytol, 218: 929-935. doi:10.1111/nph.14619 |
| Keywords: |
arginylation; cysteine oxidation; N-degron; N-end rule pathway; N-recognins; N-terminomics; proteases; ubiquitin-proteasome system; |
| Academic Unit: |
Faculty of Science and Engineering > Biology |
| Item ID: |
11022 |
| Identification Number: |
https://doi.org/10.1111/nph.14619 |
| Depositing User: |
Emmanuelle Graciet
|
| Date Deposited: |
05 Sep 2019 13:38 |
| Journal or Publication Title: |
New Phytologist |
| Publisher: |
Wiley |
| Refereed: |
No |
| Funders: |
Agence Nationale de la Recherche, Department of Agriculture, Food and the Marine, Science Foundation Ireland (SFI), Virtual Irish Centre for Crop Improvement, European Regional Development Fund, Deutsche Forschungsgemeinschaft |
| URI: |
|
| Use Licence: |
This item is available under a Creative Commons Attribution Non Commercial Share Alike Licence (CC BY-NC-SA). Details of this licence are available
here |
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